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Additionally, a hydrogen bond concerning the amide of 71a bond and Ser357, π–π interaction concerning indazole and Trp423 and π-cation interactions amongst indazole and Lys470 ended up also noticed. Conversely, only two hydrogen bond interactions of indazole with Gly533 and Ser 601 had been doable in the Get It Here case from the docking studies of 71a with BRAF V599E.
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Further, the terminal phenyl moiety of 97g participated in π–π interaction with Phe699. This was also noticed while in the docking review of 97r. Also, the oxygen on the tricyclic ring of 97r was noticed to kind a hydrogen bond with Met769, whereas the nitrogen with the quinoxaline group participated in hydrogen bonding with Asp831 and lys721.
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